Resveratrol Supplements

Resveratrol Perspectives

Frank — Sun, 27 Jun 2010 06:17:52 +0000

Resveratrol is a known antioxidant that is found mainly in red wine, and probably ensures that the French suffer rare despite delicate diet with lots of cheese, sausage fat and white bread to vascular disease and heart weakness.

Positive effects of moderate consumption of red wine on blood vessels and circulation has what, Gunk explains gynecologist Dr. Bernd Kleine-in his book Resveratrol - longer young with the red wine-Medicine.

Presented in a range of studies (see below refs): mice that were fed resveratrol as a supplement to their traditional diet. It was observed the mice stayed much healthier during their lifespan. Even in older mice; heart, muscles, eyes and bone structure appeared healther compared to the control group.

Resveratrol appears to mimic the effects of a starvation diet, such as the Okinawa diet, without its potential drawbacks, such as constant freezing, sexual pain, and extreme deprivation

David Sinclair of Harvard University, says: “For the first time we can bring the benefits of calorie restriction in a healthy animal.” Sinclair has long been a supporter of the benefits of resveratrol and its associated enzyme, SIRT1.

Calorie restrictive diet also activates this enzyme, SIRt1 in the family Surtuine that regulate cell function and control the regeneration of cell power plants (mitochondria).

Conflicting Analysis

First, this analysis was performed only on mice and the effects on the human organism are not yet clear.

Second, Sinclair is not only a scientists but also the former owner of a pharmaceutical company that produces and distributes resveratrol and other anti-aging products. This suggests a possible conflict of interest regarding published research findings.

Despite claims about how compound, resveratol, stimulates the body’s production of antioxidants to counter the effects free radicals, the body of research is not conclusive at this time. And further research is required.

The ambiguiety of the resveratrol research does not seem to hamper the development of commercial products containing resveratrol. For example, Glaxo Smith Kline sees opportunity for resveratrol in the markets of anti-aging and body weight loss / management.

In short, there appears to be enough evidence to indicate a relationship between resveratrol and health benefit claims, however a miricle drug is it not. But rather a supplement to a well balanced diet and healthy lifestyle.

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

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French Paradox

Frank — Sun, 27 Jun 2010 03:31:05 +0000

Reports from Epidemiologists in the early 1990s contained an unusual observation. In France, especially in the south of the country, the heart attack rate was about 30-40 percent lower than in comparable European countries and the United States. This observation was in spite high rates of smoking and high cholesterol diets.

As a result of these studies and others, the term French Paradox was first presented by Dr. Serge Renaud, a scientist from Bordeaux University in France (1)

The high consumption of red wine became known as the French cardioprotective effect. The research isolated, Resveratrol, as the active concentrate in the trends of lower heart disease rates in the French cohort (2).

Subsequent investigations are central to explain the French paradox. Large cohort studies like those of Klatsky could with moderate alcohol consumption decreases cardiovascular disease demonstrate regardless of what type of alcohol was consumed (3). The Copenhagen City Heart Study documented the generally cardioprotective effects of alcohol, wine drinker but found a slightly lower overall mortality compared to beer drinkers (4).

The acting agent in red wine, namely, Resveratrol continues to attract research and media atteniton as scientists debate the its health and biological.

(1) Simini (2000). “Serge Renaud: from French paradox to Cretan miracle”.

(2) Hung, LM, et al. Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovasc. Cardiovasc. Res. 47 (2000) 549-555. Res 47 (2000)

(3) Klatsky AL, Armstrong MA, Friedman, GD Red wine, white wine, liquor, beer and risk for coronary artery disease hospitalization. Am. Am. J. Cardiol. J. Cardiol. 80 (1997) 416-420. 80 (1997)

(4) Gronbaek, M., et al. Mortality Associated with Moderate Intakes of Wine, Beer, or Spirits. Brit. Brit. Med. J. 310 (1995) 1165-1169. Med J. 310 (1995)

Resveratrol. Key to longer lifespan?

Resveratrol. Key to longer lifespan?

Frank — Sat, 26 Jun 2010 07:47:08 +0000

Resveratrol is widely regarded as the “active ingredient of red wine.” It is mainly the grape skin and in lower concentrations in the grape seeds, stems, vines and roots of the vine in front. It can also be a number of other food crops such as peanuts and mulberries prove, however.

It was first isolated in 1940 from the leaves of the white lily. Has the highest content of Japanese knotweed Polygonum cuspidatum. This medicinal plant is both in traditional Japanese medicine under the name Ko-jo-kon as well as in Indian Ayurvedic medicine as Darakchasava widespread (1). Resveratrol gained international recognition but not until the 1990s, mainly as a possible explanation for the “French paradox” (2).

Resveratrol belongs to the large group of polyphenols. The exact name of the grape in this effective form is the Trans-,4,5-trihydroxystilben third. In fact, it resembles the chemical structure of resveratrol of the synthetic estrogen diethylstilbestrol.

Biological molecule that acts as a phytoalexin. In other words, resveratrol is part of the plant’s immune system. Its main function is to protect the grapes against fungal, bacterial and viral infections as well as from environmental influences such as UV radiation, ozone, and toxins (3).

Since the phytoalexin acts mainly as a fungicide, grapes usually contain high concentrations of resveratrol.

The manufacturing process of red wine usually has a higher content than white wine, since the mash when extorted juice stay longer. The polyphenol is soluble in alcohol, which explains why more of that wine contains grape juice.

References

1Paul, B., et al. Occurrence of resveratrol and in Pterostilbene age-old Darakchasava on Ayurvedic medicine from India. J. Ethnopharmocol. J. Ethnopharmocol. 68 (1999) 71-76. 68 (1999) 71-76.

2 Renaud, S., de Lorgeril, M., Wine, Alcohol, Platelets and the French Paradox for Coronary Heart Disease. Renaud, S., de Lorgeril, M. Wine, alcohol, platelets and the French Paradox for Coronary Heart Disease. Lancet 339 (1992) 1523-1526. Lancet 339 (1992) from 1523 to 1526.

3 Ignatowicz, E., Baer-Dubowska, W., resveratrol, a natural chemopreventive agent against degenerative diseases. Pol. Pol. J. Pharmacol. J. Pharmacol. 53 (6) (2001) 557-569. 53 (6) (2001) 557–569

French Paradox

Resveratrol Supplements in the News

Frank — Fri, 31 Jul 2009 14:09:03 +0000

Clinical research

New studies released from the Harvard Medical School and Institute of Genetics and Molecular Biology found that Resveratrol, a natural antioxidant compound found in the skin of dark grapes, may significantly reduce risks of:

heart disease
age ralated illnesses; Alzheimer’s disease
counter effects of high fat diet
prolong life spans in clinical animal studies

Scientific Lab animals tests

extended life 30%
reduce heart disease
control osteoporosis
weight management additive acai and green tea

Harvard Study, Joseph Barr author

“This could arguably be the biggest medical discovery since antibiotics.”

Resveratrol In the media:

WebMD: “Red wine ingredient may delay aging.”
CNN: “At high doses, resveratrol appears to prolong life spans and improve health in mice. Human trials are underway.”
Fox News: “It’s the Holy Grail of aging research.”

Do you suffer from lower energy levels? Bloating and constipation?

Resveratrol is proving to significantly increase the number of mitochondria in the muscle cells, which are responsible for generating your cells’ energy. The increased mitochondria allow you to burn more calories and thus avoid weigh gain.

Live a healthy Life

Live Healthy
Extend your Life
Protect your Heart
Feel young again
Feel extra healthy

Expanding pools of research about Resveratrol supplements

Frank — Sat, 18 Jul 2009 04:48:45 +0000

Resveratrol supplements, are proving to contain many powerful health and lifestyle benefits. Health claims include: anti-aging properties; better energy levels; weight loss resulting from calorie burning and diverse benefits for the cardiovascular scheme.

Nearly all sources of data relating to resveratrol note admired media personalities such as Oprah Winfrey, who presented interviews with Dr. Oz, a Turkish medical expert, who discussed scientific results suggesting links between resveratrol and anti-aging processes in laboratory experiments involving mice and other small animals such as fish and rats. Media publicity is not unusual principally when covering so called ‘wonder pills’ or ‘fountain of youth’ claims. But, the claims made by media personalities and talk show hosts do have some scientific support. Lets take a look at some of the promising ‘evidence’.

One of my other articles contains a sample of video reports on the scientific claims about resveratrol (Wikipedia Info).

Resveratrol Antioxidant Properties

Before we can comprehend the antioxidant character of resveratrol supplements, we need to look at the function of oxidants. Oxidants (Wikipedia) are a type of toxin that attacks organs in the body and are related to cancer producing cells. Antioxidants, as the name implies, are the direct opposite of oxidants. They offer protection for body cells, organs and the central nervous system. As a result, antioxidants contend with toxic oxidants and repair damaged cell tissue.

Resveratrol Sources

Many common foods and drinks contain resveratrol. For instance, red wine is one rich source of resveratrol. Red grapes, of course, and peanuts also contain elements of resveratrol. According to a promising body of scientific studies, the health outcomes require high-level concentrations of the resveratrol compound, not found in standard foods. This explains the emerging supply of resveratrol supplements available. Resveratrol supplements are acquired from sources namely: Japanese knotweed and red wine.

Resveratrol and slowing the Aging Process

Resveratrol supplements usually contain 500 times more of the resveratrol compound than is found in everyday foods. These are the type of concentrations used in laboratory tests reported in the media. One of the core claims from the scientific studies is the relationship between resveratrol and extending life duration. Although these studies are rather new and ongoing, there seems to be salient evidence to prop up the claims. Specifically these claims include benefits such as: fighting diseases linked with diabetes and cancer. The lab experiments involving mice and rats showed improved life expectancy when exposed to high concentrations of reveratrol supplements in their diets.

The theory stemming for the research examines how resveratrol incites the SIRT-1 gene. The action of this gene is initiated by a calorie deprived diet. The lab experiments showed that when rats are given high concentrations of resveratrol or fed on low calorie diets, they show longer and more active life spans when compared to control groups. Sirtris Pharmaceuticals is one company conducting human tests with the drug, SRT501 for its application for controlling diabetes. Other findings point to some promise for retarding the natural aging process and improving cardiovascular systems as we age.

In other studies, Stanford University researchers effectively reversed the aging of skin in mice by introducing resveratrol into their diets. The resveratrol motivated the skin cells to rapidly reproduce. While these findings are in their infancy, cosmetic companies are paying close attention for commercial applications of resveratrol in the cosmetics market sector.

What are the options for accessing quality resveratrol supplements?

Next time you’re out shopping look for health food stores and browse their inventory for supplies of resveratrol supplements. Do the same at your local store. Also talk to the store owners about resveratrol. Then again, look online. There are loads of online opportunities for buying resveratrol supplements. In some cases you will find websites offering convenient links to merchants offering free trials of resveratrol supplement packs. The only initial cost involved is the shipping fees. Some advice, study the terms of the free trial offers. Usually the terms require you cancel and return the offer if you decide you do not want to pay the full price after the end of the trial period.

In conclusion, the information and opinions contained this article are based on researched information from publically available sources. Therefore, the information does not comprise medical advice or scientific fact. Commercially available resveratrol supplements are not approved by the FDA for any health condition. For any specific health condition, talk to a professional medical doctor.

Resveratrol extracts and supplements, when combined with a balanced diet and some moderate exercise, can deliver several long term health benefits.

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Resveratrol Supplements - Consumer advice

Frank — Sat, 11 Jul 2009 08:19:11 +0000

In other articles on my site you will find key findings from a range of scientific studies promoting the health, weight management and anti-aging benefits of Resveratrol supplements.

Media channels continue to discuss and report on the anti-aging and weight loss benefits of Resveratrol. Oprah and the Rachel Ray show plus CNN and 60 minutes, are notable examples. Time and Fortune magazines also run stories and reports on scientific findings related to Resveratrol and its associated health benefits.

Resveratrol research and development for application in the form of supplements is a focus for bioceutical companies, as noted in the following video clip.

“Could a pill that’s designed to treat type 2 diabetes also be the first anti-aging drug? The pills are based on a substance (Resveratrol) in, of all things, red wine.”

Do you dream about waking up in the mornings with a youthful spring in your step and maintain a positive and energetic positive attitude throughout the day? Do you crave an easy dietary supplement to enhance your weight loss program? Well, Resveratrol and its derivative supplements is one powerful answer.

The problem faced when reviewing Resveratrol supplement products is the range of choice available, especially those merchants offering a free trial offer. In my opinion, most of the free trial type offers available online are very similar. The supplements all share the key compound ‘Resveratrol’, a powerful anti-aging compound.

Based on my research and personal experience, the product Resveratrol, satisfies a range of desirable criteria:

Slow down aging
Extend life span
Assist weight loss
Protect the heart
Enhance energy levels

Media reports (USA Today) stress the importance for consumers to research and check Resveratrol details to ensure the product specifications accurately state the supplement’s contents and extract composition.

Resveratrol composition form a potent antioxidant power pack for enhancing the body’s natural processes for managing anti-aging and weight control. boost your energy levels, reduce stomach bloating and constipation that result from inappropriate intake.

I hope this article has helped you make a better decision about which Resveratrol supplement product is right for you. Visit my homepage for additional reports.

Reported Health Benefits of Resveratrol Supplements

Frank — Fri, 10 Jul 2009 04:44:39 +0000

Media reports about resveratrol supplements and the release of scientific studies about the health benefits of Resveratrol (wikipedia reference) has sparked a broad interest and appetite for Resveratrol and related supplements. Media personalities such as Oprah and Barbara Walters on programs such as 60 minutes and CNN have propelled Resveratrol into the public psyche.

This article will focus on the anti-aging benefits of Resveratrol supplements. Other articles on my site will discuss related benefits such as weigh management and control.

Resveratrol is a compound found naturally in the dark skin variety of grapes. The extract from grape skins contains powerful antioxidants such as anthocyanadin. Antioxidents have been proved to assist in free radicals in the body and are related to the natural aging process. Scientists have evidence that the antioxidant compounds of Resveratrol are effective in countering the effects of free radicals involved in the aging process, resulting in a slowing of aging in controlled lab tests.

Other media reports include NBC Nightly News. In the following clip we see Brian Williams report discussing Resveratrol.

Resveratrol extract has proven to be effective against cardiovascular diseases due to its anti oxidant properties. The power of antioxidant carriers is their ability to prevent cell damage by the body’s free radicals.

Although resveratrol extract is found on red grape skins and of course red wine, the concentrations are small. This explains the popularity of Resveratrol supplements for their higher concentrations of the key ingredient, Resveratrol.

The major component in managing the effects of cell aging is the effect of Resveratrol SIRT1 gene. This gene is responsible for activating and triggering the protein and enzyme sirtuin. Sirtuin is often referred to as a ‘protector of cells’ and aids in cell repair. Sirtuin stimulates cells to self-repair in the fight against disease. Now in terms resveratrol the amounts in red wine are insufficient to stimulate the SIRT1. This is where the benefits of Resveratrol supplements can be found and utilized for managing the aging process.

The SIRT1 enzyme is also believed by many scientists to enhance the activity of the mitochondria, the enzyme in cells that provide cells with the energy to process fats.

For example, laboratory tests, mice given resveratrol extracts demonstrated higher energy levels consistent with a boost in the number and quality of mitochondria within their body cells. The studies also report an increase in muscle tissue. The theory held by the scientists is that these lab results can be safely applied to humans with beneficial health effects such as a reduction in the number and efficiency of the mitochondria within the cells.

Attention by chemists and bioceutical companies continues. And it is likely we will see more studies released proving the health, anti-aging, and weight management benefits of Resveratrol. At the moment, Resveratol supplements of superior quality and concentrations provides effective access to the reports health and lifestyle benefits. The internet is an effective resource for researching and learning both about the nature of Resveratrol and buying Resveratrol supplements. In fact several websites offer free trials of Resveratrol pills sent directly to your address simply by providing your details and paying the basic shipping costs. These kinds of offers are an ideal way to try-before-you-buy.

I hope this article provides some useful insights into the power of Resveratrol supplements for improving lifestyle habits.

Resveratrol An Overview: Potent Natural Immune System - Supplement Boost

Frank — Wed, 08 Jul 2009 15:19:34 +0000

What is Resveratrol?

Resveratrol and associated dietary supplements, is an antioxidant frequently found in plants. Red wine, peanuts, grapes and blueberries contain traces this natural antioxidant. More concentrated sources of Resveratrol include grape seed and red wine extracts. Other rich sources of this humble nutrient are found in white hellebore roots and the Japanese knotweed. More recently biochemists have focused their research attention on the properties of red wine for sources of Resveratrol. Red wine is proving to contain higher concentrations of Resveratrol.

Resveratrol in the N.Y. Times.

In particular the Muscadine grape variety contains commercially viable amounts of Resveratrol for the purpose of producing Resveratrol antioxidant products.

Resveratrol supplements are a new and easy way to access a range reported health benefits that include: cardiovascular health and cholesterol reduction. Biochemists continue to research this potent antioxidant and bioceutical companies focus their efforts on producing an increasing range of supplement products.

Encouraging research studies demonstrate that Resveratrol contains potent cancer fighting properties, can reduce blood sugar levels and slow cellular aging processes. Scientists have investigated the occurrence of resveratrol in red wine to explain the “French Paradox”, a theory to explain low rates heart disease in France and other Mediterranean populations.

Technically, Resveratrol belongs to a class of antibiotic compounds called phytoalexins. These naturally occurring compounds in plants produce protection against disease. Scientists have isolated these antioxidant compounds (additional readings) and developed applications for use by humans. Resveratrol supplements are now the result and contain high concentrations of Resveratrol antioxidants.

As further evidence of the emerging health benefits, check out this youtube video attached below…

Sirtris and Harvard Discover potent enzymes to Slow the Aging processes - Data Published in the Journal Cell. Discovery Reveals Critical Role of SIRT3 and SIRT4 in Cell Metabolism. New Pathway research for Developing Treatments for Diseases resulting from Aging